Key Role of Local Regulation in Chemosensing Revealed by a New Molecular Interaction-Based Modeling Method

• Martin Meier-Schellersheim ,

  *To whom correspondence should be addressed. E-mail: rgermain@niaid.nih.gov (RNG, general correspondence); mms@niaid.nih.gov (MMS, specific correspondence about Simmune)

  Affiliation Lymphocyte Biology Section and Program in Systems Immunology and Infectious Disease Modeling, Laboratory of Immunology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, United States of America

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• Xuehua Xu,

  Affiliation Laboratory of Immunogenetics, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rockville, Bethesda, Maryland, United States of America

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• Bastian Angermann,

  Affiliations Lymphocyte Biology Section and Program in Systems Immunology and Infectious Disease Modeling, Laboratory of Immunology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, United States of America , Institute for Theoretical Physics, Faculty for Mathematics and Natural Sciences, University of Hamburg, Hamburg, Germany

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• Eric J Kunkel,

  Affiliation BioSeek, Inc., Burlingame, California, United States of America

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• Tian Jin,

  Affiliation Laboratory of Immunogenetics, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rockville, Bethesda, Maryland, United States of America

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• Ronald N Germain

  *To whom correspondence should be addressed. E-mail: rgermain@niaid.nih.gov (RNG, general correspondence); mms@niaid.nih.gov (MMS, specific correspondence about Simmune)

  Affiliation Lymphocyte Biology Section and Program in Systems Immunology and Infectious Disease Modeling, Laboratory of Immunology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, United States of America

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