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Dynamically-Driven Inactivation of the Catalytic Machinery of the SARS 3C-Like Protease by the N214A Mutation on the Extra Domain

  • Jiahai Shi ,

    Contributed equally to this work with: Jiahai Shi, Nanyu Han

    Affiliation Department of Biological Sciences, Faculty of Science, National University of Singapore, Singapore

  • Nanyu Han ,

    Contributed equally to this work with: Jiahai Shi, Nanyu Han

    Affiliation School of Biological Sciences, Nanyang Technological University, Singapore

  • Liangzhong Lim,

    Affiliation Department of Biological Sciences, Faculty of Science, National University of Singapore, Singapore

  • Shixiong Lua,

    Affiliation Department of Biological Sciences, Faculty of Science, National University of Singapore, Singapore

  • J. Sivaraman,

    Affiliation Department of Biological Sciences, Faculty of Science, National University of Singapore, Singapore

  • Lushan Wang,

    Affiliation State Key Laboratory of Microbial Technology, Shandong University, Jinan, China

  • Yuguang Mu ,

    bchsj@nus.edu.sg (JS); YGMu@ntu.edu.sg (YM)

    Affiliation School of Biological Sciences, Nanyang Technological University, Singapore

  • Jianxing Song

    bchsj@nus.edu.sg (JS); YGMu@ntu.edu.sg (YM)

    Affiliations Department of Biological Sciences, Faculty of Science, National University of Singapore, Singapore, Department of Biochemistry, Yong Loo Lin School of Medicine and National University of Singapore, Singapore

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