An Evolutionary Trade-Off between Protein Turnover Rate and Protein Aggregation Favors a Higher Aggregation Propensity in Fast Degrading Proteins

• Greet De Baets,

  Affiliations VIB Switch Laboratory, VIB, Brussels, Belgium, Vrije Universiteit Brussel, Brussels, Belgium

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• Joke Reumers,

  Affiliations VIB Switch Laboratory, VIB, Brussels, Belgium, Vrije Universiteit Brussel, Brussels, Belgium

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• Javier Delgado Blanco,

  Affiliations VIB Switch Laboratory, VIB, Brussels, Belgium, Vrije Universiteit Brussel, Brussels, Belgium

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• Joaquin Dopazo,

  Affiliations Department of Bioinformatics and Genomics, Centro de Investigación Príncipe Felipe (CIPF), Valencia, Spain, CIBER de Enfermedades Raras (CIBERER), Valencia, Spain, Functional Genomics Node (INB) at CIPF, Valencia, Spain

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• Joost Schymkowitz ,

  * E-mail: frederic.rousseau@switch.vib-vub.be (FR); joost.schymkowitz@switch.vib-vub.be (JS)

  Affiliations VIB Switch Laboratory, VIB, Brussels, Belgium, Vrije Universiteit Brussel, Brussels, Belgium

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• Frederic Rousseau

  * E-mail: frederic.rousseau@switch.vib-vub.be (FR); joost.schymkowitz@switch.vib-vub.be (JS)

  Affiliations VIB Switch Laboratory, VIB, Brussels, Belgium, Vrije Universiteit Brussel, Brussels, Belgium

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