A Semi-Quantitative, Synteny-Based Method to Improve Functional Predictions for Hypothetical and Poorly Annotated Bacterial and Archaeal Genes

• Alexis P. Yelton,

  Affiliation Department of Environmental Science, Policy, and Management, University of California, Berkeley, California, United States of America

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• Brian C. Thomas,

  Affiliation Department of Environmental Science, Policy, and Management, University of California, Berkeley, California, United States of America

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• Sheri L. Simmons,

  Current address: Josephine Bay Paul Center for Molecular Biology and Evolution, Marine Biological Laboratory, Woods Hole, Massachusetts, United States of America.

  Affiliation Department of Earth and Planetary Sciences, University of California, Berkeley, California, United States of America

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• Paul Wilmes,

  Current address: Department of Environment and Agro-Biotechnologies, Centre de Recherche Public – Gabriel Lippmann, Belvaux, Grand-Duchy of Luxembourg.

  Affiliation Department of Earth and Planetary Sciences, University of California, Berkeley, California, United States of America

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• Adam Zemla,

  Affiliation Physical and Life Sciences Directorate, Lawrence Livermore National Laboratory, Livermore, California, United States of America

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• Michael P. Thelen,

  Affiliation Physical and Life Sciences Directorate, Lawrence Livermore National Laboratory, Livermore, California, United States of America

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• Nicholas Justice,

  Affiliation Department of Plant and Microbial Biology, University of California, Berkeley, California, United States of America

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• Jillian F. Banfield

  * E-mail: jbanfield@berkeley.edu

  Affiliations Department of Environmental Science, Policy, and Management, University of California, Berkeley, California, United States of America, Department of Earth and Planetary Sciences, University of California, Berkeley, California, United States of America

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