The Ability of Flux Balance Analysis to Predict Evolution of Central Metabolism Scales with the Initial Distance to the Optimum

• William R. Harcombe,

  Affiliation Department of Organismic and Evolutionary Biology, Harvard University, Cambridge, Massachusetts, United States of America

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• Nigel F. Delaney,

  Current address: Department of Medicine, Massachusetts General Hospital, Boston, Massachusetts, United States of America.

  Affiliation Department of Organismic and Evolutionary Biology, Harvard University, Cambridge, Massachusetts, United States of America

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• Nicholas Leiby,

  Affiliations Department of Organismic and Evolutionary Biology, Harvard University, Cambridge, Massachusetts, United States of America, Systems Biology Program, Harvard University, Cambridge, Massachusetts, United States of America

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• Niels Klitgord,

  Current address: Life Sciences Division, Lawrence Berkeley National Laboratory, Berkeley, Massachusetts, United States of America.

  Affiliation Bioinformatics Graduate Program, Boston University, Boston, Massachusetts, United States of America

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• Christopher J. Marx

  * E-mail: cmarx@oeb.harvard.edu

  Affiliations Department of Organismic and Evolutionary Biology, Harvard University, Cambridge, Massachusetts, United States of America, Faculty of Arts and Sciences Center for Systems Biology, Harvard University, Cambridge, Massachusetts, United States of America

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