Prediction of Drug-Target Interactions for Drug Repositioning Only Based on Genomic Expression Similarity

Kejian Wang; Jiazhi Sun; Shufeng Zhou; Chunling Wan; Shengying Qin; Can Li; Lin He; Lun Yang

doi:10.1371/journal.pcbi.1003315

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Open Access

Peer-reviewed

Research Article

Prediction of Drug-Target Interactions for Drug Repositioning Only Based on Genomic Expression Similarity

Kejian Wang,

Affiliation Bio-X Institutes, Key Laboratory for the Genetics of Developmental and Neuropsychiatric Disorders, Shanghai Jiao Tong University, Shanghai, China
⨯
Jiazhi Sun,

Affiliation Department of Pharmaceutical Sciences, College of Pharmacy, University of South Florida, Tampa, Florida, United States of America
⨯
Shufeng Zhou,

Affiliation Department of Pharmaceutical Sciences, College of Pharmacy, University of South Florida, Tampa, Florida, United States of America
⨯
Chunling Wan,

Affiliation Bio-X Institutes, Key Laboratory for the Genetics of Developmental and Neuropsychiatric Disorders, Shanghai Jiao Tong University, Shanghai, China
⨯
Shengying Qin,

Affiliation Bio-X Institutes, Key Laboratory for the Genetics of Developmental and Neuropsychiatric Disorders, Shanghai Jiao Tong University, Shanghai, China
⨯
Can Li,

Affiliation Bio-X Institutes, Key Laboratory for the Genetics of Developmental and Neuropsychiatric Disorders, Shanghai Jiao Tong University, Shanghai, China
⨯
Lin He ,

* E-mail: helinhelin3@gmail.com, kejianwang1984@gmail.com (LH); Lun.Yang@gmail.com (LY)

Affiliation Bio-X Institutes, Key Laboratory for the Genetics of Developmental and Neuropsychiatric Disorders, Shanghai Jiao Tong University, Shanghai, China
⨯
Lun Yang

* E-mail: helinhelin3@gmail.com, kejianwang1984@gmail.com (LH); Lun.Yang@gmail.com (LY)

Current address: GlaxoSmithKline R&D, Philadelphia, Pennsylvania, United States of America.

Affiliation Bio-X Institutes, Key Laboratory for the Genetics of Developmental and Neuropsychiatric Disorders, Shanghai Jiao Tong University, Shanghai, China
⨯

Prediction of Drug-Target Interactions for Drug Repositioning Only Based on Genomic Expression Similarity

Kejian Wang,
Jiazhi Sun,
Shufeng Zhou,
Chunling Wan,
Shengying Qin,
Can Li,
Lin He,
Lun Yang

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Published: November 7, 2013
https://doi.org/10.1371/journal.pcbi.1003315

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