Feedback Signals in Myelodysplastic Syndromes: Increased Self-Renewal of the Malignant Clone Suppresses Normal Hematopoiesis

• Thomas Walenda ,

  Contributed equally to this work with: Thomas Walenda, Thomas Stiehl

  Affiliation Helmholtz Institute for Biomedical Engineering, RWTH Aachen University Medical School, Aachen, Germany

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• Thomas Stiehl ,

  Contributed equally to this work with: Thomas Walenda, Thomas Stiehl

  Affiliation Interdisciplinary Center of Scientific Computing (IWR), Institute of Applied Mathematics, University of Heidelberg, Heidelberg, Germany

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• Hanna Braun,

  Affiliation Helmholtz Institute for Biomedical Engineering, RWTH Aachen University Medical School, Aachen, Germany

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• Julia Fröbel,

  Affiliation Department of Hematology, Oncology and Clinical Immunology, Heinrich-Heine-University Düsseldorf, Düsseldorf, Germany

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• Anthony D. Ho,

  Affiliation Department of Medicine V, Medical Center, University of Heidelberg, Heidelberg, Germany

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• Thomas Schroeder,

  Affiliation Department of Hematology, Oncology and Clinical Immunology, Heinrich-Heine-University Düsseldorf, Düsseldorf, Germany

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• Tamme W. Goecke,

  Affiliation Department of Obstetrics and Gynecology, RWTH Aachen University Medical School, Aachen, Germany

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• Björn Rath,

  Affiliation Department for Orthopedics, RWTH Aachen University Medical School, Aachen, Germany

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• Ulrich Germing,

  Affiliation Department of Hematology, Oncology and Clinical Immunology, Heinrich-Heine-University Düsseldorf, Düsseldorf, Germany

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• Anna Marciniak-Czochra,

  Affiliation Interdisciplinary Center of Scientific Computing (IWR), Institute of Applied Mathematics, University of Heidelberg, Heidelberg, Germany

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• Wolfgang Wagner

  * E-mail: wwagner@ukaachen.de

  Affiliation Helmholtz Institute for Biomedical Engineering, RWTH Aachen University Medical School, Aachen, Germany

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