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Research Article

Intrinsic Disorder Is a Common Feature of Hub Proteins from Four Eukaryotic Interactomes

  • Chad Haynes,

    Affiliation: Laboratory of Statistical Genetics, The Rockefeller University, New York, New York, United States of America

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  • Christopher J Oldfield,

    Affiliation: Center for Computational Biology and Bioinformatics, Indiana University School of Medicine, Indianapolis, Indiana, United States of America

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  • Fei Ji,

    Affiliation: Laboratory of Statistical Genetics, The Rockefeller University, New York, New York, United States of America

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  • Niels Klitgord,

    Affiliation: Center for Cancer Systems Biology and Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, Massachusetts, United States of America

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  • Michael E Cusick,

    Affiliation: Center for Cancer Systems Biology and Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, Massachusetts, United States of America

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  • Predrag Radivojac,

    Affiliation: Indiana University School of Informatics, Bloomington, Indiana, United States of America

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  • Vladimir N Uversky,

    Affiliations: Center for Computational Biology and Bioinformatics, Indiana University School of Medicine, Indianapolis, Indiana, United States of America, Institute for Biological Instrumentation, Russian Academy of Sciences, Moscow, Russia

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  • Marc Vidal,

    Affiliations: Center for Cancer Systems Biology and Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, Massachusetts, United States of America, Department of Genetics, Harvard Medical School, Boston, Massachusetts, United States of America

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  • Lilia M Iakoucheva mail

    To whom correspondence should be addressed. E-mail: lilia@rockefeller.edu

    Affiliation: Laboratory of Statistical Genetics, The Rockefeller University, New York, New York, United States of America

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  • Published: August 04, 2006
  • DOI: 10.1371/journal.pcbi.0020100

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