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Research Article

Analysis of Sequence Conservation at Nucleotide Resolution

  • Saurabh Asthana,

    Affiliation: Division of Genetics, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, United States of America

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  • Mikhail Roytberg,

    Affiliation: Computational Biology Group, Institute of Mathematical Problems in Biology, Russian Academy of Sciences, Pushchino, Russia

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  • John Stamatoyannopoulos mail,

    To whom correspondence should be addressed. E-mail: ssunyaev@rics.bwh.harvard.edu (SS), jstam@u.washington.edu (JS)

    Affiliation: Department of Genome Sciences, University of Washington, Seattle, Washington, United States of America

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  • Shamil Sunyaev mail

    To whom correspondence should be addressed. E-mail: ssunyaev@rics.bwh.harvard.edu (SS), jstam@u.washington.edu (JS)

    Affiliation: Division of Genetics, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, United States of America

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  • Published: December 28, 2007
  • DOI: 10.1371/journal.pcbi.0030254

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