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Research Article

Diminished Self-Chaperoning Activity of the ΔF508 Mutant of CFTR Results in Protein Misfolding

  • Adrian W. R. Serohijos equal contributor,

    equal contributor Contributed equally to this work with: Adrian W. R. Serohijos, Tamás Hegedűs

    Affiliation: Department of Physics and Astronomy, University of North Carolina Chapel Hill, Chapel Hill, North Carolina, United States of America

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  • Tamás Hegedűs equal contributor,

    equal contributor Contributed equally to this work with: Adrian W. R. Serohijos, Tamás Hegedűs

    Affiliations: Department of Biochemistry and Biophysics, University of North Carolina Chapel Hill, Chapel Hill, North Carolina, United States of America, Cystic Fibrosis Research Center, University of North Carolina Chapel Hill, Chapel Hill, North Carolina, United States of America

    X
  • John R. Riordan,

    Affiliations: Department of Biochemistry and Biophysics, University of North Carolina Chapel Hill, Chapel Hill, North Carolina, United States of America, Cystic Fibrosis Research Center, University of North Carolina Chapel Hill, Chapel Hill, North Carolina, United States of America

    X
  • Nikolay V. Dokholyan mail

    dokh@med.unc.edu

    Affiliation: Department of Biochemistry and Biophysics, University of North Carolina Chapel Hill, Chapel Hill, North Carolina, United States of America

    X
  • Published: February 29, 2008
  • DOI: 10.1371/journal.pcbi.1000008

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