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Research Article

Natural Selection Fails to Optimize Mutation Rates for Long-Term Adaptation on Rugged Fitness Landscapes

  • Jeff Clune mail,

    jclune@msu.edu

    Affiliations: Department of Computer Science and Engineering, Michigan State University, East Lansing, Michigan, United States of America, Instituto de Biología Molecular y Celular de Plantas, Consejo Superior de Investigaciones Cientificas, Universidad Politecnica de València, València, Spain

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  • Dusan Misevic,

    Affiliation: Institute of Integrative Biology, ETH Zurich, Zurich, Switzerland

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  • Charles Ofria,

    Affiliation: Department of Computer Science and Engineering, Michigan State University, East Lansing, Michigan, United States of America

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  • Richard E. Lenski,

    Affiliation: Department of Microbiology and Molecular Genetics, Michigan State University, East Lansing, Michigan, United States of America

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  • Santiago F. Elena,

    Affiliations: Instituto de Biología Molecular y Celular de Plantas, Consejo Superior de Investigaciones Cientificas, Universidad Politecnica de València, València, Spain, The Santa Fe Institute, Santa Fe, New Mexico, United States of America

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  • Rafael Sanjuán

    Affiliations: Instituto de Biología Molecular y Celular de Plantas, Consejo Superior de Investigaciones Cientificas, Universidad Politecnica de València, València, Spain, Institut Cavanilles de Biodiversitat i Biologia Evolutiva, Universitat de València, València, Spain

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  • Published: September 26, 2008
  • DOI: 10.1371/journal.pcbi.1000187

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