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Research Article

Dose-to-Duration Encoding and Signaling beyond Saturation in Intracellular Signaling Networks

  • Marcelo Behar,

    Affiliations: Department of Physics, University of North Carolina Chapel Hill, Chapel Hill, North Carolina, United States of America, Program in Cellular and Molecular Biophysics, University of North Carolina Chapel Hill, Chapel Hill, North Carolina, United States of America

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  • Nan Hao,

    Affiliation: Department of Pharmacology, University of North Carolina Chapel Hill, Chapel Hill, North Carolina, United States of America

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  • Henrik G. Dohlman,

    Affiliations: Department of Pharmacology, University of North Carolina Chapel Hill, Chapel Hill, North Carolina, United States of America, Department of Biochemistry and Biophysics, University of North Carolina Chapel Hill, Chapel Hill, North Carolina, United States of America

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  • Timothy C. Elston mail

    telston@med.unc.edu

    Affiliation: Department of Pharmacology, University of North Carolina Chapel Hill, Chapel Hill, North Carolina, United States of America

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  • Published: October 10, 2008
  • DOI: 10.1371/journal.pcbi.1000197

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