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Research Article

Designing Focused Chemical Libraries Enriched in Protein-Protein Interaction Inhibitors using Machine-Learning Methods

  • Christelle Reynès,

    Affiliation: Inserm UMR-S 973/MTi, University Paris Diderot, Paris, France

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  • Hélène Host,

    Affiliations: CDithem Platform/IGM, Paris, France, Inserm UMR-S 761, Institut Pasteur de Lille, Lille, France, Université Lille 2, Faculté des Sciences Pharmaceutiques et Biologiques, Lille, France

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  • Anne-Claude Camproux,

    Affiliation: Inserm UMR-S 973/MTi, University Paris Diderot, Paris, France

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  • Guillaume Laconde,

    Affiliations: CDithem Platform/IGM, Paris, France, Inserm UMR-S 761, Institut Pasteur de Lille, Lille, France, Université Lille 2, Faculté des Sciences Pharmaceutiques et Biologiques, Lille, France

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  • Florence Leroux,

    Affiliations: CDithem Platform/IGM, Paris, France, Inserm UMR-S 761, Institut Pasteur de Lille, Lille, France, Université Lille 2, Faculté des Sciences Pharmaceutiques et Biologiques, Lille, France

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  • Anne Mazars,

    Affiliations: CDithem Platform/IGM, Paris, France, UMR-S940, Hôpital St Louis, Paris, France

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  • Benoit Deprez,

    Affiliations: CDithem Platform/IGM, Paris, France, Inserm UMR-S 761, Institut Pasteur de Lille, Lille, France, Université Lille 2, Faculté des Sciences Pharmaceutiques et Biologiques, Lille, France

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  • Robin Fahraeus,

    Affiliations: CDithem Platform/IGM, Paris, France, UMR-S940, Hôpital St Louis, Paris, France

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  • Bruno O. Villoutreix,

    Affiliations: Inserm UMR-S 973/MTi, University Paris Diderot, Paris, France, CDithem Platform/IGM, Paris, France

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  • Olivier Sperandio mail

    olivier.sperandio@univ-paris-diderot.fr

    Affiliations: Inserm UMR-S 973/MTi, University Paris Diderot, Paris, France, CDithem Platform/IGM, Paris, France

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  • Published: March 05, 2010
  • DOI: 10.1371/journal.pcbi.1000695

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