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Research Article

Quantitative Comparison of Catalytic Mechanisms and Overall Reactions in Convergently Evolved Enzymes: Implications for Classification of Enzyme Function

  • Daniel E. Almonacid,

    Affiliations: Department of Bioengineering and Therapeutic Sciences, University of California San Francisco, San Francisco, California, United States of America, Department of Pharmaceutical Chemistry, University of California San Francisco, San Francisco, California, United States of America, California Institute for Quantitative Biosciences, University of California San Francisco, San Francisco, California, United States of America

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  • Emmanuel R. Yera,

    Affiliation: Biological and Medical Informatics Graduate Program, University of California San Francisco, San Francisco, California, United States of America

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  • John B. O. Mitchell,

    Affiliation: Centre for Biomolecular Sciences, University of St Andrews, St Andrews, United Kingdom

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  • Patricia C. Babbitt mail

    babbitt@cgl.ucsf.edu

    Affiliations: Department of Bioengineering and Therapeutic Sciences, University of California San Francisco, San Francisco, California, United States of America, Department of Pharmaceutical Chemistry, University of California San Francisco, San Francisco, California, United States of America, California Institute for Quantitative Biosciences, University of California San Francisco, San Francisco, California, United States of America

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  • Published: March 12, 2010
  • DOI: 10.1371/journal.pcbi.1000700

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