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Research Article

Mathematical Modelling of DNA Replication Reveals a Trade-off between Coherence of Origin Activation and Robustness against Rereplication

  • Anneke Brümmer,

    Affiliations: Research Group Modelling of Biological Systems (B086), German Cancer Research Center, Heidelberg, Germany, BioQuant Center, Heidelberg, Germany

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  • Carlos Salazar,

    Affiliations: Research Group Modelling of Biological Systems (B086), German Cancer Research Center, Heidelberg, Germany, BioQuant Center, Heidelberg, Germany

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  • Vittoria Zinzalla,

    Affiliation: Biozentrum, University of Basel, Basel, Switzerland

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  • Lilia Alberghina mail,

    lilia.alberghina@unimib.it (LA); t.hoefer@dkfz-heidelberg.de (TH)

    Affiliation: Department of Biotechnology and Biosciences, Università degli Studi di Milano-Bicocca, Milan, Italy

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  • Thomas Höfer mail

    lilia.alberghina@unimib.it (LA); t.hoefer@dkfz-heidelberg.de (TH)

    Affiliations: Research Group Modelling of Biological Systems (B086), German Cancer Research Center, Heidelberg, Germany, BioQuant Center, Heidelberg, Germany

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  • Published: May 13, 2010
  • DOI: 10.1371/journal.pcbi.1000783

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