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Research Article

Modeling Mechanisms of In Vivo Variability in Methotrexate Accumulation and Folate Pathway Inhibition in Acute Lymphoblastic Leukemia Cells

  • John C. Panetta mail,

    carl.panetta@stjude.org

    Affiliations: Department of Pharmaceutical Sciences, St. Jude Children's Research Hospital, Memphis, Tennessee, United States of America, Colleges of Medicine and Pharmacy, University of Tennessee, Memphis, Tennessee, United States of America

    X
  • Alex Sparreboom,

    Affiliations: Department of Pharmaceutical Sciences, St. Jude Children's Research Hospital, Memphis, Tennessee, United States of America, Colleges of Medicine and Pharmacy, University of Tennessee, Memphis, Tennessee, United States of America

    X
  • Ching-Hon Pui,

    Affiliations: Colleges of Medicine and Pharmacy, University of Tennessee, Memphis, Tennessee, United States of America, Department of Oncology, St. Jude Children's Research Hospital, Memphis, Tennessee, United States of America

    X
  • Mary V. Relling,

    Affiliations: Department of Pharmaceutical Sciences, St. Jude Children's Research Hospital, Memphis, Tennessee, United States of America, Colleges of Medicine and Pharmacy, University of Tennessee, Memphis, Tennessee, United States of America

    X
  • William E. Evans

    Affiliations: Department of Pharmaceutical Sciences, St. Jude Children's Research Hospital, Memphis, Tennessee, United States of America, Colleges of Medicine and Pharmacy, University of Tennessee, Memphis, Tennessee, United States of America

    X
  • Published: December 02, 2010
  • DOI: 10.1371/journal.pcbi.1001019

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