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Research Article

Establishment and Validation of Computational Model for MT1-MMP Dependent ECM Degradation and Intervention Strategies

  • Daisuke Hoshino,

    Affiliation: Division of Cancer Cell Research, Institute of Medical Science, University of Tokyo, Minato-ku, Tokyo, Japan

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  • Naohiko Koshikawa,

    Affiliation: Division of Cancer Cell Research, Institute of Medical Science, University of Tokyo, Minato-ku, Tokyo, Japan

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  • Takashi Suzuki,

    Affiliations: Division of Mathematical Science, Graduate School of Engineering Science, Osaka University, Toyonaka, Osaka, Japan, JST, CREST, Chiyoda-ku, Tokyo, Japan

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  • Vito Quaranta,

    Affiliation: Department of Cancer Biology, Vanderbilt University Medical Center, Nashville, Tennessee, United States of America

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  • Alissa M. Weaver,

    Affiliation: Department of Cancer Biology, Vanderbilt University Medical Center, Nashville, Tennessee, United States of America

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  • Motoharu Seiki mail,

    mseiki@ims.u-tokyo.ac.jp

    Affiliations: Division of Cancer Cell Research, Institute of Medical Science, University of Tokyo, Minato-ku, Tokyo, Japan, JST, CREST, Chiyoda-ku, Tokyo, Japan

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  • Kazuhisa Ichikawa

    Affiliations: JST, CREST, Chiyoda-ku, Tokyo, Japan, Division of Mathematical Oncology, Institute of Medical Science, University of Tokyo, Minato-ku, Tokyo, Japan

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  • Published: April 12, 2012
  • DOI: 10.1371/journal.pcbi.1002479

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