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Research Article

Literature Based Drug Interaction Prediction with Clinical Assessment Using Electronic Medical Records: Novel Myopathy Associated Drug Interactions

  • Jon D. Duke equal contributor,

    equal contributor Contributed equally to this work with: Jon D. Duke, Xu Han, Zhiping Wang

    Affiliation: Regenstrief Institute, Indianapolis, Indiana, United States of America

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  • Xu Han equal contributor,

    equal contributor Contributed equally to this work with: Jon D. Duke, Xu Han, Zhiping Wang

    Affiliations: Department of Pharmacology and Toxicology, School of Medicine, Indiana University, Indianapolis, Indiana, United States of America, Division of Clinical Pharmacology, Department of Medicine, School of Medicine, Indiana University, Indianapolis, Indiana, United States of America

    X
  • Zhiping Wang equal contributor,

    equal contributor Contributed equally to this work with: Jon D. Duke, Xu Han, Zhiping Wang

    Affiliations: Center for Computational Biology and Bioinformatics; School of Medicine, Indiana University, Indianapolis, Indiana, United States of America, Department of Medical and Molecular Genetics, School of Medicine, Indiana University, Indianapolis, Indiana, United States of America

    X
  • Abhinita Subhadarshini,

    Affiliation: Center for Computational Biology and Bioinformatics; School of Medicine, Indiana University, Indianapolis, Indiana, United States of America

    X
  • Shreyas D. Karnik,

    Affiliation: Center for Computational Biology and Bioinformatics; School of Medicine, Indiana University, Indianapolis, Indiana, United States of America

    X
  • Xiaochun Li,

    Affiliation: Department of Biostatistics, School of Medicine, Indiana University, Indianapolis, Indiana, United States of America

    X
  • Stephen D. Hall,

    Affiliation: Eli Lilly Inc., Indianapolis, Indiana, United States of America

    X
  • Yan Jin,

    Affiliation: Eli Lilly Inc., Indianapolis, Indiana, United States of America

    X
  • J. Thomas Callaghan,

    Affiliation: Division of Clinical Pharmacology, Department of Medicine, School of Medicine, Indiana University, Indianapolis, Indiana, United States of America

    X
  • Marcus J. Overhage,

    Affiliation: Siemens, Malvern, Pennsylvania, United States of America

    X
  • David A. Flockhart,

    Affiliations: Department of Pharmacology and Toxicology, School of Medicine, Indiana University, Indianapolis, Indiana, United States of America, Division of Clinical Pharmacology, Department of Medicine, School of Medicine, Indiana University, Indianapolis, Indiana, United States of America, Center for Computational Biology and Bioinformatics; School of Medicine, Indiana University, Indianapolis, Indiana, United States of America, Department of Medical and Molecular Genetics, School of Medicine, Indiana University, Indianapolis, Indiana, United States of America, Indiana Institute of Personalized Medicine, School of Medicine, Indianapolis, Indiana, United States of America

    X
  • R. Matthew Strother,

    Affiliations: Division of Clinical Pharmacology, Department of Medicine, School of Medicine, Indiana University, Indianapolis, Indiana, United States of America, Division of Hematology and Oncology, Department of Medicine, Indiana University, Indianapolis, Indiana, United States of America

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  • Sara K. Quinney,

    Affiliations: Division of Clinical Pharmacology, Department of Medicine, School of Medicine, Indiana University, Indianapolis, Indiana, United States of America, Indiana Institute of Personalized Medicine, School of Medicine, Indianapolis, Indiana, United States of America, Department of Obstetrics and Gynecology, School of Medicine, Indiana University, Indianapolis, Indiana, United States of America

    X
  • Lang Li mail

    lali@iupui.edu

    Affiliations: Division of Clinical Pharmacology, Department of Medicine, School of Medicine, Indiana University, Indianapolis, Indiana, United States of America, Center for Computational Biology and Bioinformatics; School of Medicine, Indiana University, Indianapolis, Indiana, United States of America, Department of Medical and Molecular Genetics, School of Medicine, Indiana University, Indianapolis, Indiana, United States of America, Department of Biostatistics, School of Medicine, Indiana University, Indianapolis, Indiana, United States of America, Indiana Institute of Personalized Medicine, School of Medicine, Indianapolis, Indiana, United States of America

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  • Published: August 09, 2012
  • DOI: 10.1371/journal.pcbi.1002614

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