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Research Article

Disease-Associated Mutations Disrupt Functionally Important Regions of Intrinsic Protein Disorder

  • Vladimir Vacic,

    Affiliation: Department of Computer Science, Columbia University, New York, New York, United States of America

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  • Phineus R. L. Markwick,

    Affiliations: Department of Chemistry and Biochemistry, University of California San Diego, La Jolla, California, United States of America, Howard Hughes Medical Institute, Chevy Chase, Maryland, United States of America

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  • Christopher J. Oldfield,

    Affiliation: Center for Computational Biology and Bioinformatics, Department of Biochemistry and Molecular Biology, Indiana University School of Medicine, Indianapolis, Indiana, United States of America

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  • Xiaoyue Zhao,

    Affiliation: Cold Spring Harbor Laboratory, Cold Spring Harbor, New York, United States of America

    Current address: Google Inc, Mountain View, California, United States of America

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  • Chad Haynes,

    Affiliation: Laboratory of Statistical Genetics, The Rockefeller University, New York, New York, United States of America

    Current address: WaterSmart Software, San Francisco, California, United States of America

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  • Vladimir N. Uversky,

    Affiliations: Department of Molecular Medicine, University of South Florida College of Medicine, Tampa, Florida, United States of America, Institute for Biological Instrumentation, Russian Academy of Sciences, Pushchino, Moscow Region, Russia

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  • Lilia M. Iakoucheva mail

    lilyak@ucsd.edu

    Affiliation: Department of Psychiatry, University of California San Diego, La Jolla, California, United States of America

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  • Published: October 04, 2012
  • DOI: 10.1371/journal.pcbi.1002709

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