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Open Access
Peer-reviewed
Research Article
Exploring Off-Targets and Off-Systems for Adverse Drug Reactions via Chemical-Protein Interactome — Clozapine-Induced Agranulocytosis as a Case Study
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Lun Yang ,
Contributed equally to this work with: Lun Yang, Kejian Wang
* E-mail: lun.yang@gmail.com (LY), lun.yang@fda.hhs.gov (LY); helinhelin3@gmail.com (LH)
Current address: Center for Bioinformatics, National Center for Toxicological Research, U.S. Food and Drug Administration, Jefferson, Arizona, United States of America
Affiliations Bio-X Center, Key Laboratory for the Genetics of Developmental and Neuropsychiatric Disorders (Ministry of Education), Shanghai Jiao Tong University, Shanghai, China, Institutes of Biomedical Sciences, Fudan University, Shanghai, China, School of Pharmacy, Fudan University, Shanghai, China
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Kejian Wang ,
Contributed equally to this work with: Lun Yang, Kejian Wang
Affiliation Bio-X Center, Key Laboratory for the Genetics of Developmental and Neuropsychiatric Disorders (Ministry of Education), Shanghai Jiao Tong University, Shanghai, China
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Jian Chen,
Affiliation Bio-X Center, Key Laboratory for the Genetics of Developmental and Neuropsychiatric Disorders (Ministry of Education), Shanghai Jiao Tong University, Shanghai, China
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Anil G. Jegga,
Affiliations Division of Biomedical Informatics, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio, United States of America, Departments of Pediatrics and Computer Science, University of Cincinnati, Cincinnati, Ohio, United States of America
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Heng Luo,
Affiliation Bio-X Center, Key Laboratory for the Genetics of Developmental and Neuropsychiatric Disorders (Ministry of Education), Shanghai Jiao Tong University, Shanghai, China
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Leming Shi,
Affiliation School of Pharmacy, Fudan University, Shanghai, China
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Chunling Wan,
Affiliation Bio-X Center, Key Laboratory for the Genetics of Developmental and Neuropsychiatric Disorders (Ministry of Education), Shanghai Jiao Tong University, Shanghai, China
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Xizhi Guo,
Affiliation Bio-X Center, Key Laboratory for the Genetics of Developmental and Neuropsychiatric Disorders (Ministry of Education), Shanghai Jiao Tong University, Shanghai, China
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Shengying Qin,
Affiliation Bio-X Center, Key Laboratory for the Genetics of Developmental and Neuropsychiatric Disorders (Ministry of Education), Shanghai Jiao Tong University, Shanghai, China
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Guang He,
Affiliation Bio-X Center, Key Laboratory for the Genetics of Developmental and Neuropsychiatric Disorders (Ministry of Education), Shanghai Jiao Tong University, Shanghai, China
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Guoyin Feng,
Affiliation Bio-X Center, Key Laboratory for the Genetics of Developmental and Neuropsychiatric Disorders (Ministry of Education), Shanghai Jiao Tong University, Shanghai, China
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Lin He
* E-mail: lun.yang@gmail.com (LY), lun.yang@fda.hhs.gov (LY); helinhelin3@gmail.com (LH)
Affiliations Bio-X Center, Key Laboratory for the Genetics of Developmental and Neuropsychiatric Disorders (Ministry of Education), Shanghai Jiao Tong University, Shanghai, China, Institutes of Biomedical Sciences, Fudan University, Shanghai, China, Institute for Nutritional Sciences, Shanghai Institute of Biological Sciences, Chinese Academy of Sciences, Shanghai, China
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Exploring Off-Targets and Off-Systems for Adverse Drug Reactions via Chemical-Protein Interactome — Clozapine-Induced Agranulocytosis as a Case Study
- Lun Yang,
- Kejian Wang,
- Jian Chen,
- Anil G. Jegga,
- Heng Luo,
- Leming Shi,
- Chunling Wan,
- Xizhi Guo,
- Shengying Qin,
- Guang He
- Published: March 31, 2011
- https://doi.org/10.1371/journal.pcbi.1002016