Following on from David B. Searls' introduction to The Roots of Bioinformatics series, Russell F. Doolittle reviews the confluence of events beginning in the 1950s that brought together a number of fields in a common pursuit in The Roots of Bioinformatics in Protein Evolution.
Image Credit: Pat Margis/Maojun Yang et al., doi/10.1371/journal.pbio.0060050
Raffaello Potestio et al. assess, on the basis of presently available structural data, the extent to which knotted proteins are isolated instances in sequence or structure space, and use comparative schemes to understand whether specific protein segments can be associated with the occurrence of a knot in the native state.
Deusdedit Lineu Spavieri Jr. et al. analyze how the representation of motion information in the fly's nervous system changes with temperature and luminance, and find that the mean firing rate, but not firing precision, changes with temperature, while both are affected by mean luminance.
Dobrowsky et al. (The Johns Hopkins University) examine the initial interaction of HIV particles with the surface of target cells. These findings could give a valuable boost to the development of new therapies preventing HIV infection.
PLoS Computational Biology is a peer-reviewed, open-access journal featuring works of exceptional significance that further our understanding of living systems at all scales through the application of computational methods. It is an official journal of the International Society for Computational Biology.
E-mail Alerts
RSS (What is RSS?)
Join PLoS
PLoS on Twitter
PLoS on FacebookRead the PLoS Blog 
and contribute your views on scientific research and open-access publishing.
All site content, except where otherwise noted, is licensed under a Creative Commons Attribution License.
