Miller et al. have developed a freely available interactive step-by-step guide for performing common molecular simulation tasks integrated into the CHARMM INterface and Graphics web user interface.
Learn more in Part I: Lessons and Tutorial, Part II: Coarse Grained Protein Folding and Part III: Reduction Potentials of Electron Transfer Proteins.
Restif et al. report on comprehensive computer vision software for analysis of swimming locomotion of C. elegans, and Amaro et al. present a multi-scale utility called LipidWrapper capable of creating curved membrane models and demonstrate its utility by examining a mechanism of influenza virulence.
Collective behaviour is a widespread phenomenon in biology, from cell colonies up to bird flocks and fish schools. Attanasi et al. perform three dimensional tracking of large swarms of midges and find that swarms display strong collective behaviour despite the absence of collective order.
Segregation within the nuclear envelope has been experimentally verified, but the nature and configuration of any plausible diffusion barrier remain unknown. Marquez-Lago et al. show how complex nuclear diffusion barriers in closed mitosis may arise from simple nanoscale biophysical interactions.
Cancer tissue is characterised by an increased variability in DNA methylation patterns. Teschendorff et al. analyse the dynamic changes in DNA methylation correlation pattern during cervical carcinogenesis, demonstrating that epigenetic diversity is maximal just prior to the onset of cancer.
PLOS Computational Biology is a peer-reviewed, open-access journal featuring works of exceptional significance that further our understanding of living systems at all scales through the application of computational methods. It is an official journal of the International Society for Computational Biology.