Restif et al. report on comprehensive computer vision software for analysis of swimming locomotion of C. elegans, and Amaro et al. present a multi-scale utility called LipidWrapper capable of creating curved membrane models and demonstrate its utility by examining a mechanism of influenza virulence.
Segregation within the nuclear envelope has been experimentally verified, but the nature and configuration of any plausible diffusion barrier remain unknown. Marquez-Lago et al. show how complex nuclear diffusion barriers in closed mitosis may arise from simple nanoscale biophysical interactions.
Cancer tissue is characterised by an increased variability in DNA methylation patterns. Teschendorff et al. analyse the dynamic changes in DNA methylation correlation pattern during cervical carcinogenesis, demonstrating that epigenetic diversity is maximal just prior to the onset of cancer.
Using a computational framework for modelling, exploring, and tracking enhanced metabolic capacities in simple microbial communities, Chia et al. demonstrate that emergent biosynthetic capacity – multiple species growing together to produce metabolites not secreted when growing alone – is common.
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