Do you have a difficult problem to solve? Katrina Pavelin and colleagues suggest holding an interactive workshop to quickly yield new ideas and solutions to this problem. They present here ten simple rules to empower readers to design and lead their own successful interactive workshops.
Maximum entropy approaches are becoming increasingly common in the field of computational biology and the general applicability of the principle suggests that there is significant potential for other relevant applications. Here, the authors provide a broad introduction to the approach in an attempt to encourage its further adoption.
Birds flying through a cluttered environment require the ability to choose routes that will take them through the environment safely and quickly. Here, the authors examine how budgerigars choose between two apertures and discover that individuals show a preference for the left- or right-hand side.
In this article, the authors show that per-base count overdispersion is a widespread and consistent phenomenon in high-throughput sequencing experiments. To compensate for this, they introduce a nonparametric and universal method for processing per-base sequencing read count data called FIXSEQ.
This is a PLOS Computational Biology Methods Article.
It is well known that, under suitable conditions, microRNAs are able to fine tune the relative concentration of their targets to any desired value. Here, Riba et al. demonstrate that this function is particularly effective when one of the targets is a Transcription Factor which regulates the other targets.
PLOS Computational Biology is a peer-reviewed, open-access journal featuring works of exceptional significance that further our understanding of living systems at all scales through the application of computational methods. It is an official journal of the International Society for Computational Biology.