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Perspective

Modeling Planarian Regeneration: A Primer for Reverse-Engineering the Worm

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In this month's perspective, Lobo et al. hope to close the gap between regenerative biology and the fields of mathematics, computer science and engineering. They present the basic features of planarian regeneration from an engineering perspective, in order to facilitate modeling approaches.

 

Review

Rise and Demise of Bioinformatics? Promise and Progress

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PLoS Computational Biology editor Christos Ouzounis explores the rise and demise of the term "bioinformatics" and how its linguistic use might reflect trends in the field, in this latest edition of our popular Editors' Outlook series.

 

Featured Research

Intermittent Motion in Desert Locusts: Behavioural Complexity in Simple Environments

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In order to understand the drivers behind the complex movement patterns of animals, Bazazi et al. examine the movement behaviour of individual desert locusts in a homogenous experimental arena with minimal external cues. Their findings offer a new perspective on how these patterns emerge in nature.

Image Credit: Bazazi et al.

 

Modeling Meiotic Chromosomes Indicates a Size Dependent Contribution of Telomere Clustering and Chromosome Rigidity to Homologue Juxtaposition

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This work by Penfold et al. represents an important development in computer modeling of chromosomes, and suggests new explanations for why elucidating the functional significance of the bouquet configuration, during meiosis, by genetics has been so difficult.

 

Deconvolution of the Cellular Force-Generating Subsystems that Govern Cytokinesis Furrow Ingression

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In this study Poirier et al. use a computational model of cellular dynamics during cytokinesis to show how various mechanical parameters quantitatively impact furrow ingression kinetics. Their results account for the cytokinesis dynamics of both wild type and mutant cell-lines.

 

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