PLoS Computational Biology: A Peer-Reviewed Open-Access Journal

Alternative Splicing in the Differentiation of Human Embryonic Stem Cells into Cardiac Precursors
A Hidden Markov Model for Single Particle Tracks Quantifies Dynamic Interactions between LFA-1 and the Actin Cytoskeleton
Evolution of Resistance to Targeted Anti-Cancer Therapies during Continuous and Pulsed Administration Strategies
Optimal Experimental Design for Parameter Estimation of a Cell Signaling Model
Looking at Cerebellar Malformations through Text-Mined Interactomes of Mice and Humans
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Collection

PLoS Collection on the Genomics of Emerging Infectious Disease

A collection of essays, perspectives, and reviews, produced with support from Google.org, describes how genomics can revolutionize our understanding of emerging infectious disease. The collection has contributions from nearly all the PLoS Journals: PLoS Computational Biology offers three Perspectives. Computational Resources in Infectious Disease: Limitations and Challenges (Eva Berglund et al.), Discovering the Phylodynamics of RNA Viruses (Edward Holmes & Bryan Grenfell) and The Role of Medical Structural Genomics in Discovering New Drugs for Infectious Diseases (Wesley Van Voorhis et al.). You can listen to an audio interview discussion of the issues raised by this collection.

Perspective

Computational Biology in Colombia

In the latest addition to our Developing Computational Biology series, Silvia Restrepo et al. discuss the past, present, and future of this emerging field in Colombian science.

Featured Research

Robust Models for Optic Flow Coding in Natural Scenes Inspired by Insect Biology

Brinkworth & O'Carroll present a full model for motion processing in the insect visual pathway incorporating known or suspected elements in as much detail as possible. The implementation of this new algorithm could provide a very useful and robust velocity estimator for artificial navigation systems.

Tipping the Balance: Robustness of Tip Cell Selection, Migration and Fusion in Angiogenesis

Here, Bentley et al. present a new theory on why angiogenesis shows such sensitivity to signalling from oxygen deficient tissue, and show that this response, when associated with diseases such as cancer, is surprisingly more robust than in normal functioning.

Steps in the Bacterial Flagellar Motor

Thierry Mora et al. propose a simple physical model of the rotation of the bacterial flagellar motor, based on the storage of energy in protein springs.

Other PLoS Content

PLoS ONE

Reverse Engineering a Signaling Network Using Alternative Inputs

October 2009 Issue

PLoS Computational Biology is a peer-reviewed, open-access journal featuring works of exceptional significance that further our understanding of living systems at all scales through the application of computational methods. It is an official journal of the International Society for Computational Biology.